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In this research paper, we delve into the profound shifts introduced by artificial intelligence (AI) within global supply chain management. Beginning with a historical examination of supply chains prior to AI's integration, the report paints a vivid picture of the cascading changes AI has ushered in and the enormous potential that lies ahead. Through an analysis of key areas, from demand forecasting to risk management, the report showcases AI's transformative capabilities. These include enhanced demand accuracy, streamlined inventory systems, more efficient warehouse operations, optimized transportation routes, and proactive maintenance strategies, among others. Particularly noteworthy is the in-depth case study of Amazon—a global leader in adopting and advancing AI within its supply chain. This case study offers a pragmatic view of AI's real-world challenges, innovative solutions, and the tangible benefits derived from its deployment.